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The four astronauts on the Artemis II mission have passed 100,000 miles from Earth as they head towards the moon, putting them on track to reach the farthest distance humans have ever travelled into space.

The crew have left Earth’s orbit and fired their engines on Thursday for a “translunar injection”, sending the Orion capsule on its trajectory towards the moon.

“Ladies and gentlemen, I am so, so excited to be able to tell you that for the first time since 1972 during Apollo 17, human beings have left Earth orbit,” Nasa’s Dr Lori Glaze told a news conference.

The astronauts, Americans Reid Wiseman, Victor Glover and Christina Koch, as well as Jeremy Hansen, a Canadian, spent their first day in space performing checks on the spacecraft, which had never carried humans before. Later they had time to speak to US TV networks.

“I’ve got to tell you, there is nothing normal about this,” Wiseman told ABC News from the cramped interior of the capsule. “Sending four humans 250,000 miles away is a herculean effort, and we are now just realising the gravity of that.”

Orion will travel about 4,000 miles beyond the moon before turning back, providing unprecedented and illuminated views of the lunar far side.

If all proceeds smoothly, the astronauts will set a record by venturing farther from Earth than any human before – more than 250,000 miles.

The mission is part of a longer-term plan to repeatedly return to the moon, with the aim of establishing a permanent base that will offer a platform for further exploration.

On Thursday, after what Nasa described as a “flawless” engine firing that lasted just under six minutes, the astronauts said they had been glued to the windows of the capsule as they left Earth.

Koch said: “There’s nothing that prepares you for the breathtaking aspect of seeing your home planet both lit up bright as day, and also the moon glow on it at night with the beautiful beam of the sunset.”

Now that the astronauts are moon-bound, there is no turning back: they are on a “free return” trajectory, which uses the moon’s gravity to slingshot around it before heading back towards Earth.

In the event something goes wrong, the astronauts are equipped with suits that also serve as “survival systems”. This means that in the unlikely case of a cabin depressurisation or leak, they will maintain oxygen, temperature controls and the correct pressure for up to six days.

They are expected to spend 30 minutes a day working out on the spacecraft’s flywheel exercise device, in order to minimise the muscle and bone loss that happens in the absence of Earth’s gravity.

The mission marks a series of historic accomplishments, including sending the first person of colour, the first woman and the first non-American on a lunar mission. It is also the inaugural crewed flight of SLS, Nasa’s lunar rocket.

After years of delays and massive cost overruns, it was meant to take off in February but was again delayed by repeated setbacks, with the rocket needing to be rolled back to its hangar for repairs.

The current era of US lunar investment has frequently been portrayed as an effort to compete with China, which aims to land humans on the moon by 2030.

During a post-launch briefing, Jared Isaacman, the Nasa administrator, said competition was “a great way to mobilise the resources of a nation”. He added: “Competition can be a good thing – and we certainly have competition now.”

The Artemis programme has come under pressure from Donald Trump, who is hoping US boots will hit the lunar surface before his second term ends in January 2029. But the projected date of 2028 for a landing has raised eyebrows among some experts, in part because Washington is relying heavily on the private sector’s technological headway.

After blasting off from the Kennedy Space Center in Florida on Wednesday, the astronauts sounded the alarm over a slight glitch: a toilet had begun malfunctioning as the crew reached orbit.

With help from mission control, Koch was guided through some plumbing tricks until she finally got it going, but not before having to resort to using contingency urine storage bags.

Koch later said she was proud to call herself “the space plumber”, noting that it had just been an issue of the equipment needing to warm up.

“I like to say that it is probably the most important piece of equipment onboard,” she added. “So we were all breathing a sigh of relief when it turned out to be just fine.”

After the crew was asked about the deep divisions at home and what message they had for Americans, Glover replied by pointing to their singular vantage point and the view it had afforded them of Earth.

“You look amazing. You look beautiful. From up here, you also look like one thing,” he said. “We’re all one people.”